Evaluation of the Male and Female Fertility and Teratogenic Effects of Lignosus rhinocerotis (Cooke) Ryvarden in Rats

Lignosus rhinocerotis (Cooke) Ryvarden (LR) or tiger milk mushroom has traditionally been used in Malaysia due to its abundant medicinal properties. The potential effects of LR on the male and female fertility teratogenicity were investigated rats. Male Sprague Dawley (10 rats/group) orally administered with 0, 250, 500 1000 mg/kg/day extract for 30 consecutive days. Female (5 received same treatment beginning dioestrus pre-mating, through mating periods continuously up day 20 pregnancy while rest females left untreated. Evaluation general health, behaviour, body weight organ weights; reproductive internal organs carried out. parameters such as performance hormones well sperm analysis examined. Maternal gross assessment at autopsy detailed foetal examination conducted determine teratogenicity. findings obtained animals showed that no significant deleterious weight, visceral performance, daily doses LR. Foetal pregnant dams did not affect rats litters. Our treatment-related toxicity all groups following treatment. herbal also result teratogenic offspring treated dams.